Continue to keep a list of the many products and solutions you employ (including prescription/nonprescription medicine and herbal solutions) and share it with all your physician and pharmacist. Usually do not start off, end, or alter the dosage of any medicines with out your doctor's acceptance.
Most MAO inhibitors must also not be taken for 2 months in advance of remedy using this medication. Talk to your medical professional when to begin or quit having this medication.
This can be associated with a decrease in efficacy, and in some individuals, might bring about signals and indicators of opioid withdrawal.
That can help protect against withdrawal, your medical professional could reduce your dose gradually. Withdrawal is much more probably When you've got utilised this medication for a long time (various months) or in substantial doses. Notify your medical doctor or pharmacist instantly Should you have withdrawal.
Drug interactions, such as an increased incidence of extrapyramidal consequences, happen to be reported when some MAOI and phenothiazines are utilised concomitantly.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals lower than 6 decades of age. Concomitant administration of promethazine products with other respiratory depressants has an Affiliation with respiratory depression, and sometimes Loss of life, in pediatric people. The association does in a roundabout way relate to individualized pounds-dependent dosing, which might normally permit Safe and sound administration.
Codeine Codeine is surely an opioid agonist rather selective for that mu-opioid receptor, but having a Significantly weaker affinity than morphine. The analgesic and antitussive Attributes of codeine have already been speculated to originate from its conversion to morphine.
This quick conversion brings about higher than envisioned serum morphine degrees. Even at labeled dosage regimens, Promethazine codeine syrup individuals who are extremely-rapid metabolizers may well knowledge overdose signs for example Extraordinary sleepiness, confusion, or shallow respiratory.
Bluish lips or pores and skin chills clay-coloured stools chilly sweats confusion cough dark urine decrease while in the frequency of urination reduce within the urine volume diarrhea tricky or troubled respiration problems in passing urine (dribbling) dizziness dizziness, faintness, or lightheadedness when obtaining up from lying or sitting down placement rapidly, pounding, or irregular heartbeat or pulse sensation of warmth fever headache superior fever hives or welts, itching, or rash amplified perspiring irregular, quick or gradual, or shallow respiratory large, hive-like swelling around the experience, eyelids, lips, tongue, throat, arms, legs, ft, or intercourse organs lack of appetite lack of bladder Handle nausea noisy breathing not breathing distressing urination pale or blue lips, fingernails, or skin rectal bleeding redness on the deal with, neck, arms, and infrequently, higher upper body redness of your skin seeing, Listening to, or feeling points that are not there seizures intense muscle mass stiffness shakiness inside the legs, arms, or arms tummy soreness perspiring tightness from the upper body tiredness trembling or shaking of your palms or ft uncomfortable breath odor unconventional tiredness or weakness unusually pale pores and skin vomiting of blood yellow eyes or pores and skin Get unexpected emergency help immediately if any of the next signs or symptoms of overdose come about:
Never get up or sit up immediately, particularly when you will be an more mature client. This minimizes the chance of dizzy or fainting spells. Alcohol could interfere with the influence of the medication. Keep away from alcoholic beverages.
Do not acquire any benzodiazepines or medicines that may cause drowsiness or sleepiness all through remedy with Promethazine Hydrochloride and Codeine Phosphate Oral Alternative. Inquire your healthcare service provider for a summary of these medicines if You're not absolutely sure.
Nearly all of scientific studies examining the usage of promethazine in pregnancy did not come across an association with a heightened risk of congenital anomalies. Within the handful of reports reporting an association, no dependable sample of malformations was observed.
This isn't an entire listing of achievable side effects. In case you detect other Unwanted effects not detailed previously mentioned, Speak to your physician or pharmacist.
Overdosage: If you think you have taken excessive of this drugs Get in touch with a poison control center or crisis home directly.